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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL5 All Species: 3.03
Human Site: S436 Identified Species: 8.33
UniProt: O76039 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76039 NP_001032420.1 1030 115538 S436 P G T K Y L K S N S R S Q Q N
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta NP_001129485 570 64691
Dog Lupus familis XP_548881 960 107395 S387 H T K T Y Q A S S Q P G S T S
Cat Felis silvestris
Mouse Mus musculus Q3UTQ8 938 105471 G369 A N E S F L N G N L A G A T L
Rat Rattus norvegicus Q5XIT0 507 57117
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514328 967 107039 Y387 S P M H A K N Y P A G G Q P G
Chicken Gallus gallus XP_425571 960 107495 N388 M H A K K S S N Q P G S G N K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001124243 1039 116666 S460 S F L E G K T S T L Q S G D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796071 627 72401 L58 E L K L L R Q L K Q E N I V E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 26.7 88.1 N.A. 85.9 23.6 N.A. 76.5 75.2 N.A. 55.3 N.A. N.A. N.A. N.A. 25.5
Protein Similarity: 100 N.A. 39.5 89.7 N.A. 88.9 36.5 N.A. 82.5 83.6 N.A. 69.1 N.A. N.A. N.A. N.A. 39
P-Site Identity: 100 N.A. 0 13.3 N.A. 13.3 0 N.A. 6.6 13.3 N.A. 13.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 N.A. 0 26.6 N.A. 20 0 N.A. 13.3 20 N.A. 26.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 12 0 12 0 12 0 0 12 12 0 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % D
% Glu: 12 0 12 12 0 0 0 0 0 0 12 0 0 0 12 % E
% Phe: 0 12 0 0 12 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 12 0 0 12 0 0 12 0 0 23 34 23 0 12 % G
% His: 12 12 0 12 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % I
% Lys: 0 0 23 23 12 23 12 0 12 0 0 0 0 0 23 % K
% Leu: 0 12 12 12 12 23 0 12 0 23 0 0 0 0 12 % L
% Met: 12 0 12 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 12 0 0 0 0 23 12 23 0 0 12 0 12 12 % N
% Pro: 12 12 0 0 0 0 0 0 12 12 12 0 0 12 0 % P
% Gln: 0 0 0 0 0 12 12 0 12 23 12 0 23 12 0 % Q
% Arg: 0 0 0 0 0 12 0 0 0 0 12 0 0 0 0 % R
% Ser: 23 0 0 12 0 12 12 34 12 12 0 34 12 0 12 % S
% Thr: 0 12 12 12 0 0 12 0 12 0 0 0 0 23 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 23 0 0 12 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _